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Related post: n (b) Human tissues
H Cataflam D (c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
TERMINATED 1991-92
10-60
PHS 6040 (Rev. 1/84)
us GOVERNUEHTPflMTNG OFFICE: 1B1 O-aW-tU
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBUC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00500-06 LID
PERIOD COVERED
October 1, 1991 to September 30, 1992
Tm.E OF PROJECT (80 characters or less. TiOe must lit on one line between the tiorders.)
Processing and Immunogenicity of Dengue Type 4 Virus Nonstructural Protein NS 1
PRINCIPAL INVESTIGATOR (Ust other protessional personnel below the Principal Investigator.) (Name, title, laboratory, and instllute affiliation)
PI: Ching-Juh Lai, Ph.D. Head, MVB Section LID, NIAID
Others: Barry Falgout, Ph.D.
Lewis Markoff, M.D.
Senior Staff Fellow
Medical Officer
LID, NIAID
LID, NIAID
COOPERATING UNITS (if any)
LAB/BRANCH
Laboratory of Infectious Diseases
SECTION
Molecular Viral Biology Section
INSTfTUTE AND LOCATION
NIAID, NTH, Bethesda, MD 20892
TOTAL MAN- YEARS:
0.5
PROFESSIONAL:
0.5
CHECK APPROPRIATE BOX(ES)
n (a) Human subjects
n (a1) Minors
D (a2) Interviews
n (b) Human tissues
(c) Neither
SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)
Previous results from our laboratory established that the N-terminal 70% of NS2A and the
C-terminal 8 amino acids of NSl are required for NS1-NS2A cleavage. To further delineate the
requirements for Cataflam Novartis NS1-NS2A cleavage, we constructed recombinant vaccinia viruses expressing
chimeric proteins consisting of PreM fused to the 3 or 8 C-terminal amino acids of NS Novartis Cataflam 1 plus NS2A.
The results showed that all of NSl, with the exception of the 8 amino acid cleavage site, is
dispensable for NS1-NS2A cleavage. Also, a signal sequence is required for cleavage to occur as
the chimeric protein SigPreM-NSl(8)-NS2A was not cleaved. This suggests that targeting to the
exocytic pathway is a prerequisite for NS1-NS2A cleavage. Additional experiments were Cataflam 50mg performed
to analyze this cleavage. Brefeldin A, a drug which blocks transport out of the Golgi, did not block
NS1/NS2A Cataflam Tablets cleavage. This suggests that NS1/NS2A cleavage occurs in the Golgi or in Cataflam 50 Mg a
compartment between the ER and the Golgi. NS1/NS2A cleavage was studied during a chase under
conditions that block ER-to-Golgi transport: incubation with the drug carbonyl cyanide m-
chlorophenylhydrazone (CCCP), or incubation at 14°C. Both of these treatments completely blocked
the chase of uncleaved NS1-NS2A precursor into NSl product. This is consistent with Cataflam 25mg the notion
that NS1/NS2A cleavage occurs after exit from the ER. Further elucidation Cataflam Diclofenac of the cleavage
mechanism is now possible using an in vitro ER-to-Golgi transport system recently developed by
others.
10-61
PHS 6040 (Rev. 1/84)
U.S.GOVB«UCNTI>RMTMGCFFICE: tw O-ttMU
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBUC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
ZOl AI 00501-05 LID
PERIOD COVERED
October 1, 1991 to September 30, 1992
TITLE OF PROJECT (80 characters or less. TiUe must Tit on one lirte between the borders.)
Study of the Processing of Dengue Viral Glycoproteins
PRINCIPAL INVESTIGATOR Buy Cataflam (List other prolessional personnel below the Principal Investigator.) (Name, title, laboratory, and institute afTiHatlon)
PI: Lewis J. Markoff, M.D. Medical Officer LID, NIAID
COOPERATING UNITS (ilany)
LAB/BRANCH
Laboratory of Infectious Diseases
SECTION
Molecular Viral Biology Section
INSTFTUTE AND LOCATION
NIAID, NIH, Bethesda, MD 20892
TOTAL MAN- YEARS;
PROFESSIONAL:
CHECK APPROPRIATE BOX(ES)
n (a) Human subjects
D (a1) Minors
D (a2) Interviews
n (b) Human tissues
S (c) Neither
SUMMARY OF WOFIK (Use standard unreduced type. Do not exceed the space provided.)
TERMINATED 1991-92
10-62
PHS 6040 (Rev. 1/84)
USLGOVSMCNTPRMrMGOmCE: ian04(MH
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBUC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT
PROJECT NUMBER
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